Gregory Grant, PhD

Gregory Grant, PhD, is professor of developmental biology and of biochemistry in medicine. He holds a joint appointments in the Department of Developmental Biology and the Department of Medicine at Washington University School of Medicine. He received a PhD in biochemistry from the University of Wisconsin-Madison in 1975 and joined the faculty at Washington University in 1978.

His research focuses on control mechanisms in allosteric enzymes and metabolic systems. He has published over 125 peer-reviewed articles in diverse enzyme systems including collagenases, snake venom neurotoxins, Fe-S enzymes, and the enzymes of serine metabolism in both E.coli and M.tuberculosis. The latter led to the discovery of the structure of the ACT domain, which is an allosteric regulatory domain that binds small molecules, mainly amino acids, that is active in a large and diverse number of proteins. His research has also led to the discovery a unique NAD/NADH cycle in E. coli that conserves NAD and allows synthesis of L-serine without net consumption of NAD. He has also published over 20 book chapters on various aspects of protein chemistry and enzymology and serves or has served on the editorial board of several major journals.

He served as President of the Association of Biomolecular Resource Facilities from 1993-1994 and  served the Washington University research community for 35 years as Director of the Protein and Nucleic Acid Chemistry Laboratory. He is currently Co-Director of the Post-Baccalaureate Program in Developmental Biology and Regenerative Medicine and a member of the Committee on Admissions for the medical school.