Latisha Love-Gregory, PhD
Dr. Latisha Love-Gregory is a research assistant professor of medicine in the Department of Medicine’s Division of Geriatrics and Nutritional Science. She earned her bachelor’s degree from Rust College summa cum laude in 1995 and her doctoral degree in genetics from the University of Missouri-Columbia in 2001. Under the mentorship of her graduate advisors, Dr. Charlotte Phillips, PhD, and Dr. Richard Hillman, MD, Dr. Love-Gregory studied and published several original manuscripts on the function and origin of ancestral mutations that cause Maple Syrup Urine Disease (MSUD) in Mennonite and non-Mennonite families.
She continued her training at Washington University School of Medicine with a postdoctoral fellowship with the late Alan Permutt, MD, a renowned diabetes researcher. Dr. Love-Gregory’s work with Dr. Permutt focused on the identification of type 2 diabetes-associated genetic variants in an Ashkenazi Jewish population. These findings contributed to a greater appreciation for population-specific risks conferred by common genetic variants. She then completed a clinical fellowship in the Department of Pathology and Immunology. She joined the Washington University faculty in 2006.
Dr. Love-Gregory’s primary research focuses on functionally characterizing genetic influences of abnormal lipid metabolism — a common link between obesity, diabetes and cardiovascular disease. She is currently investigating genetic changes in the CD36 gene, which encodes a fatty acid transporter involved in lipid uptake and metabolism. Her published studies have shown that common genetic changes in the CD36 gene increase the risk of the metabolic syndrome and influence individual differences in lipid profiles. Her long-term goals include determining the clinical utility of functional genetic risk variants for individual risk stratification and patient management.